Scientists discuss in 'Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity' new findings in ischemia. "Nitroxyl (HNO) donor compounds function as potent vasorelaxants, improve myocardial contractility and reduce ischemia-reperfusion injury in the cardiovascular system. With respect to the nervous system, HNO donors have been shown to attenuate NMDA receptor activity and neuronal injury, suggesting that its production may be protective against cerebral ischemic damage," researchers in Hamburg, Germany report (see also Ischemia).
"Hence, we studied the effect of the classical HNO-donor, Angeli's salt (AS), on a cerebral ischemia/reperfusion injury in a …
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